Background: There are many types of human papillomavirus (HPV), and the related diseases have caused a serious disease burden in the world. Our research aims to explore the epidemiological characteristics of HPV and the transmissibility of different genotypes.<br><br>Methods: Collect HPV testing data from Xiamen Maternal and Child Health Hospital and determine the research scope. The transmission dynamics model of HPV was established to simulate the transmission of different genotypes of HPV, and the transmissibility of different genotypes of HPV was estimated by comparing the effective reproduction number (<i>R<sub>eff</sub></i>).<br><br>Results: The collected HPV subjects are mainly concentrated in Xiamen, Zhangzhou and Quanzhou, and there are differences in the distribution of HPV infection among different age groups. The overall fitting effect of the model is good, and the interval range of <i>R</i><sub>2</sub> is (0.138,0.530), both of which are statistically significant. Among all HPV genotypes, 13 have <i>R<sub>eff</sub></i> values exceeding 1, among which 10 are high-risk types; The top five genotypes are HPV56, 18, 58, 52 and 53, among which the top four genotypes are high-risk and HPV53 is non-high-risk, with values of 3.34 (range: 0.00-29.09), 3.20 (range: 0.00-8.70), 3.19 (range: 0.00-15.58), 3.19 (range: 0.00-12.73) and 2.99 (range: 0.00-19.50). Among genotypes with <i>R<sub>eff</sub></i> value over 1, HPV52 has the longest duration (about 51 months).<br><br>Conclusion: Most high-risk HPV types in the hokkien golden triangle have certain transmission risks, including non-vaccine types. The region needs further optimization in the development of HPV vaccine and the design of detection methods.<br><br>Funding Information: This study was partly supported by the Bill & Melinda Gates Foundation (INV-005834) and the XMU 296 Training Program of Innovation and Enterpreneurship for Undergraduates (2021X0938).<br><br>Declaration of Interests: The authors declare no conflict of interest.<br><br>Ethics Approval Statement: The study was approved by the Ethics 114 Committee of Xiamen Maternal and Child Health Hospital. <br>